Systemic risks like climate change, cyber security and pandemics are characterised by high complexity, uncertainty, ambiguity, and effects beyond the system in which they originate. That’s why novel research approaches and regulatory measures are indispensable for the evaluation and management of these risks. An interdisciplinary team around IASS Scientific Director Ortwin Renn recently published a paper on this subject, which appears as the first article in a special issue of the journal “Risk Analysis” edited by Renn and IASS Research Group Leader Pia-Johanna Schweizer.